Genomic Analysis of BRCA2, and a Comparative Phylogenetic Analysis of BRCA2 in Humans along Different Species: A Candidate for Breast Cancer in Humans

Abstract

1. Abstract
In DNA homologous recombination repair (HRR) several proteins are encoded by BRCA1 and BRCA2. Any mutation in HRR pathway increase risk of tumor formation as a result of DNA destroying factors like salts of platinum, anthracyclines and novel agents that can damage the DNA homologous repair pathway in the form of inhibitors.